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VERSION:2.0
CALSCALE:GREGORIAN
PRODID:UW-Madison-Physics-Events
BEGIN:VEVENT
SEQUENCE:0
UID:UW-Physics-Event-1832
DTSTART:20101022T210000Z
DURATION:PT1H0M0S
DTSTAMP:20260506T161039Z
LAST-MODIFIED:20101018T194916Z
LOCATION:2241 Chamberlin Hall (coffee at 3:30 pm)
SUMMARY:Morphogen gradient formation in subdiffusive media\, Physics D
 epartment Colloquium\, Katja Lindenberg\, UC-San Diego
DESCRIPTION:Morphogens are signaling molecules that act directly on ce
 lls to produce specific cellular responses dependent on morphogen conc
 entration.  The morphogens are produced at a point in space at a const
 ant rate\, move around in the cell\, and are also subject to degradati
 on at a rate that may depend on location. The resulting morphogen conc
 entration gradients determine which response is produced where in the 
 cell or in a group of cells.<br>
\n<br>
\nThe shape of the gradient is
  obviously important in this process\, and this shape is determined by
  the way the morphogens move and degrade in the cell.  While different
  degradation processes have been considered in the literature\, the mo
 tion of the morphogens is almost always assumed to be diffusive in spi
 te of the barriers and traps presented by the crowded cellular environ
 ment. We explore the consequences of subdiffusive motion\, that is\, m
 orphogen motion that is impeded by the obstacles in the environment.  
 We conclude that morphogen concentration profiles are very sensitive n
 ot only to the details of the degradation process but also to the morp
 hogen motion.
URL:https://www.physics.wisc.edu/events/?id=1832
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