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VERSION:2.0
CALSCALE:GREGORIAN
PRODID:UW-Madison-Physics-Events
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SEQUENCE:0
UID:UW-Physics-Event-3284
DTSTART:20140310T210000Z
DURATION:PT1H0M0S
DTSTAMP:20260419T212148Z
LAST-MODIFIED:20140205T212514Z
LOCATION:Chamberlin Hall 4274
SUMMARY:How\, when and where in pattern formation: Spying on embryonic
  development one molecule at a time\, Faculty Candidate Seminar\, Hern
 an Garcia\, Princeton
DESCRIPTION:An abiding mystery in the study of living matter is how a 
 single cell develops into a multicellular organism. As this cell divid
 es\, its progeny read the program encoded on their DNA and adopt diffe
 rent fates becoming familiar cell types such as those found in muscle\
 , liver and our brains. We now know that the decisions that cells make
  during development are not so much based on which genes to express\, 
 but rather on when\, where and how to express them. Despite advances i
 n determining the identities of the molecules that mediate these decis
 ions we are still incapable of predicting how simple physical paramete
 rs such as the number\, position and affinity of binding sites for the
 se molecules on the DNA determine developmental fates. Using the fruit
  fly\, one of the classic model systems for embryonic development\, I 
 will show how a combination of new technologies\, quantitative experim
 ents\, and statistical mechanics is providing new insights about cellu
 lar decision making during development. In particular\, I will describ
 e how the specification of macroscopic body parts in an organism is li
 nked to the non-equilibrium molecular-scale processes inside single ce
 lls. The goal of this interdisciplinary research is to produce a predi
 ctive understanding of developmental programs which will enable the ra
 tional control of biological size\, shape and function.
URL:https://www.physics.wisc.edu/events/?id=3284
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