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VERSION:2.0
CALSCALE:GREGORIAN
PRODID:UW-Madison-Physics-Events
BEGIN:VEVENT
SEQUENCE:1
UID:UW-Physics-Event-5099
DTSTART:20191011T203000Z
DURATION:PT1H0M0S
DTSTAMP:20260415T060951Z
LAST-MODIFIED:20191007T203759Z
LOCATION:2241 Chamberlin Hall
SUMMARY:X-ray Free Electron Lasers (XFELs) for structural biology and 
 more: How the (relatively) new European XFEL really can do more!\, Phy
 sics Department Colloquium\, Adrian Mancuso
DESCRIPTION:X-ray Free Electron Lasers (XFELs) are relatively new\, la
 rge scale scientific facilities producing X-ray pulses of femtoseconds
  duration and unprecedented brilliance. These
\npulses provide a wealt
 h of applications across the physical and life sciences particularly t
 hrough utilizing their ability to probe ultrafast processes\, radiatio
 n
\ndamage sensitive systems or simply weakly scattering (poor cross-s
 ection) systems
\nthat require many photons—and sometimes many spati
 ally coherent photons—to
\nobserve. Of particular note is the field 
 of serial crystallography\, which holds
\npromise to make the study of
  medically and environmentally relevant proteins both
\nbroader than a
 t present and perhaps more robust.
\nNotwithstanding XFELs’ contribu
 tions to many fields from magnetism to structural
\nbiology their appl
 ication has\, in part\, been limited by access (most only allow a
\nsi
 ngle experiment at a time) and the data rate that can be achieved in a
  given
\nexperiment (most sources provide a maximum of 120 pulses per 
 second).
\nMuch more recently\, a new class of XFEL has been inaugurat
 ed in the Hamburg
\nmetropolitan area of Germany. The European XFEL is
  capable of providing up to
\n27\,000 pulses per second as well as ser
 ving distinct photon beams to three experiments
\nsimultaneously. In t
 his presentation I will outline the basic properties of the European
\
 nXFEL and how this vastly improved capability can be leveraged for bio
 molecular
\nstructure determination at the atomic scale\, not only for
  static systems but also for
\nsystems evolving in time. Schedule perm
 itting\, I will also describe possible applications
\nto observing dyn
 amic processes in materials sciences on the micrometer and
\nmicroseco
 nd timescale. Along the way I’ll outline why structural biology (sti
 ll)
\nrequires physicists\, as well as some of the open (physical) que
 stions that need to be
\naddressed before XFELs can be applied to the 
 most challenging structure determination
\nproblems in biology. To clo
 se\, I’ll look forward to what we might hope can be imaged
\nwith XF
 ELs in the not too distant future.
URL:https://www.physics.wisc.edu/events/?id=5099
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