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VERSION:2.0
CALSCALE:GREGORIAN
PRODID:UW-Madison-Physics-Events
BEGIN:VEVENT
SEQUENCE:3
UID:UW-Physics-Event-6762
DTSTART:20220429T203000Z
DURATION:PT1H0M0S
DTSTAMP:20260414T152709Z
LAST-MODIFIED:20220428T142331Z
LOCATION:2103 Chamberlin Hall
SUMMARY:Structural Dynamics in Biology using LCLS\, Physics Department
  Colloquium\, Mark Hunter\, SLAC
DESCRIPTION:The resolution revolution of cryo-EM for experimental stru
 cture determination of biomacromolecules combined with the breakthroug
 h results of AlphaFold and its derivatives for structure prediction of
  biomacromolecules have ushered in a new era in structural biology. Th
 is poses the question of what is the place for x-ray crystallography a
 nd x-ray Free Electron Lasers (xFELs) such as the Linac Coherent Light
  Source (LCLS) in structural biology moving forward? We believe that o
 ne compelling area of research using LCLS is studying the structural d
 ynamics of biomacromolecules. LCLS and other xFELs offer very high tem
 poral resolution combined with atomic spatial resolution while elimina
 ting the ill effects of conventional radiation damage. This unique com
 bination will facilitate the study of both triggered and stochastic bi
 ological dynamics. For example\, the spatiotemporal resolving power of
  LCLS can be used to study the initial photophysics and photochemistry
  in light-sensitive proteins as well as short time points in an enzyma
 tic reaction between a biomacromolecule and substrate. The structural 
 methods can also be combined with powerful complimentary techniques\, 
 such as x-ray absorption and emission spectroscopies\, to understand t
 he structure and chemical environment of biomacromolecules. The presen
 tation will cover the unique properties of LCLS and the upcoming upgra
 des to LCLS-II and LCLS-II-HE and how we can use a variety of addition
 al technologies and methodologies to access a myriad of biologically r
 elevant time scales.
URL:https://www.physics.wisc.edu/events/?id=6762
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