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VERSION:2.0
CALSCALE:GREGORIAN
PRODID:UW-Madison-Physics-Events
BEGIN:VEVENT
SEQUENCE:2
UID:UW-Physics-Event-6825
DTSTART:20220909T203000Z
DTEND:20220909T230000Z
DTSTAMP:20260414T154348Z
LAST-MODIFIED:20220907T142514Z
LOCATION:2103 Chamberlin Hall
SUMMARY:Cherenkov Imaging in Humans\, during Radiation Therapy\, Physi
 cs Department Colloquium\, Brian W. Pogue\, UW-Madison
DESCRIPTION:Radiotherapy is the controlled delivery of high energy MV 
 and MeV radiation to human tissue\, in a manner that maximizes damage 
 to cancer tissues\, while minimizing damage to normal tissues. The con
 trol of this delivery and visualization of it requires several advance
 d technologies for guidance.  An example is the use of time-gated Cher
 enkov imaging as a tool for the therapists to see what is happening wi
 thin the room where the treatment is occurring.  The invention and dev
 elopment of this approach will be outlined\, where single photon imagi
 ng is achieved with full ambient room lighting.  Additionally\, these 
 cameras can be used for scintillator spot imaging as a way to achieve 
 non-contact radiation dose measurement. 
\nA recent offshoot of this w
 ork has been in the setting of ultra-high dose rate radiation delivery
 \, which has been termed “FLASH’ radiotherapy.  This technique use
 s dose rates >40 Gy/s and instantaneous dose rates of >105 Gy/s to del
 iver the radiation\, and has an apparent normal tissue sparing effect.
  This technique has become intensely investigated in the last 5 years\
 , because it holds potential for a revolutionary change in how radiati
 on therapy is delivered.  The hypothesized models of this ‘FLASH’ 
 effect and the physio-chemical measurements to discern the mechanisms 
 will be reviewed\, along with the Cherenkov based dosimetry methods be
 ing developed.  
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\nBiography
\nBrian W. Pogue\, PhD is Cha
 ir of the Department of Medical Physics at the University of Wisconsin
 -Madison\, and Professor of Medical Physics\, Radiology and Human Onco
 logy\, and Adjunct Professor of Engineering at Dartmouth. Dr Pogue’s
  work in the area of optical imaging devices to guide cancer therapies
 \, has led to the invention of a unique system for imaging radiation d
 ose with Cherenkov emission\, and another unique approach to imaging h
 ypoxia during surgical resection. Each of these is supported by NIH fu
 nding\, and this translational work led to co-founding of three start-
 ups companies DoseOptics LLC\, QUEL Imaging LLC and Hypoxia Surgical L
 LC. This work has led to US Patents\, with 12 issued and 29 pending\, 
 and more than 450 peer-reviewed papers. Dr Pogue is a Fellow member of
  Optica\, SPIE\, AIMBE\, and the National Academy of Inventors\, and i
 s the Editor-in-Chief of the Journal of Biomedical Optics.
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URL:https://www.physics.wisc.edu/events/?id=6825
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