Abstract: Characterizing neurofluid dynamics is crucial, as it plays essential roles in maintaining cerebral homeostasis through nutrient delivery, waste clearance, and other vital functions. Disruption of these systems has been linked to a range of neurological disorders such as Alzheimer’s disease, small vessel disease, and dementia. Understanding these systems in the living human brain has been a significant challenge due to the lack of safe and reliable imaging methods, which has limited the potential for early diagnosis and preventive care. Recent advancements in MRI have enabled safe, repeatable, and high-resolution visualization of neurofluid dynamics. However, characterizing cerebrospinal fluid (CSF) dynamics still faces challenges due to the difficulties in accurately delineating CSF. In this talk, I will present MRI methods for noninvasive, high-contrast, and artifact-reduced CSF imaging, along with noninvasive cerebral blood flow analysis.